CBD stands for cannabidiol, which is a cannabinoid in the Cannabis sativa plant. Scientists have identified over 100 cannabinoids naturally present in the cannabis plant. CBD is one of these cannabinoids.
Cannabidiol comes in lots of shapes and forms, and can be used as, for example:
People have long used Cannabis in traditional medicine to treat many different diseases. Most of the medical properties of cannabis are attributable to the non-psychoactive compound cannabidiol (CBD).
Scientists have been investigating CBD for several therapeutic properties, because they believe believed that it has many medicinal properties. Experiments have shown that CBD is not addictive, and it is safe to use.
Among others, CBD acts on the cannabinoid receptors – but what are those?
Receptors are proteins that are the “eyes” and the “ears” of the cells. They receive messages from the blood and tell the cells what to do.
Endocannabinoid receptors are receptors in the human body. Several types exist, and these are the two main ones:
Endocannabinoids are internal cannabinoids that bind to the cannabinoid receptors. Together with the receptors they form the endocannabinoid system.
The endocannabinoid system regulates many systems and processes in the body, including:
When the endocannabinoid system is not working properly, certain illnesses occur. As such, phytocannabinoids, especially the non-psychotropic CBD, have very high therapeutic potential.
The reason for this is that CBD has a wide spectrum of action, meaning it acts on many aspects of our body. For example, in addition to the cannabinoid receptors, it also acts on or modulates the function of other receptors as well, especially in the brain.
CBD’s promise as a medicine comes from its potential:
Additionally, CBD has beneficial effects in
Given that CBD induces cell death (apoptosis) in cancer cells but not in healthy cells, it has potentials in the treatment of various forms of cancer.
Several research studies have examined the effect of CBD, and they identified 18 areas with therapeutic potential.
In preclinical laboratory (in vitro) and animal experiments, CBD had the following effect:
As such, CBD has shown potential as an inflammation suppressant.
Read more about CBD against inflammation (btw, you can find the same link at the bottom of this article, so keep reading…)
In animal models, CBD alleviated neuropathic pain associated with chemotherapy (paclitaxel and cisplatin treatment)
In animal experiments, CBD treatment
The administration of THC but not CBD produced psychoactive effects.
However, when both THC and CBD were administered together in a ratio of 1:10:
CBD injections into the brains of experimental animals reduced depressive behaviors.
Patients with acute schizophrenia have elevated anandamide levels, which are inversely associated with psychotic symptoms. Administration of CBD increases anandamide levels, suggesting the role of CBD in regulating psychosis.
Additionally, CBD prevented THC-induced psychosis and suppressed symptoms of psychosis with negligible side effects.
CBD suppressed obsessive compulsive behavior in animal models.
The anti-epileptic and anticonvulsant properties of CBD are probably due to its ability to suppress the generation of seizures by blocking sodium channels and nerve impulse (action potential firing) in neurons.
A 2:48 minute long animation video about CBD for epilepsy
In animal models, CBD inhibited neuronal degeneration and astrogliosis.
CBD in combination with THC:
Moreover, mesenchymal stem cells treated with CBD
In animal models, CBD reduced both insulitis and the prevalence of diabetes.
In cell culture laboratory and animal experiments, CBD
Scientists found these effects for:
CBD exhibited its anti-cancer properties acting in cancer cells only by:
In many of the experiments, a combination of CBD and THC (mostly in a ratio of 1:1) synergistically amplified anti-tumor effects.
The most effective treatment was when traditional cancer therapies – either radiation or cancer medications (such as bortezomib or carfilzomib for myeloma) – were combined with a blend of CBD and THC.
Read more about CBD oil for cancer (btw, you can find the same link at the bottom of this article, so keep reading…)
In animal models of asthma and COPD, CBD:
In animal models of inflammatory bowel disease (Crohn’s disease and ulcerative colitis), CBD:
In animal models of autoimmune myocarditis, CBD:
Consequently, CBD reduced:
A 3:36 minute long animation video about CBD for autoimmune disorders
In animal models of hypoxic ischemic brain damage, CBD administered after the incident reduced:
In vitro studies of liver fibrosis, oral CBD administration resulted in:
In animal models of malaria, CBD:
In animal models of multiple sclerosis, both CBD and palmitoylethanolamide (PEA) administered separately, decreased:
However, coadministration of CBD and PEA antagonistically reduced the therapeutic effect.
On the DNA level, CBD:
Noreen, N., Muhammad, F., Akhtar, B., Azam, F., Anwar, M.I. Is cannabidiol a promising substance for new drug development? A review of its potential therapeutic applications (2018) Critical Reviews in Eukaryotic Gene Expression, 28 (1), pp. 73-86.