Treatment with CBD

18 proven CBD oil benefits

This article is about 18 proven CBD oil benefits and answers the following questions:

What does CBD stand for?

CBD stands for cannabidiol, which is a cannabinoid in the Cannabis sativa plant. Scientists have identified over 100 cannabinoids naturally present in the cannabis plant. CBD is one of these cannabinoids.

What is CBD oil?

Cannabidiol comes in lots of shapes and forms, and can be used as, for example:

  • Oil or tincture (also called CBD oil)
  • Topical cream
  • Aerosol spray
  • Foods and drinks
  • Vape juice for smoking or inhaling

People have long used Cannabis in traditional medicine to treat many different diseases. Most of the medical properties of cannabis are attributable to the non-psychoactive compound cannabidiol (CBD). 

Scientists have been investigating CBD for several therapeutic properties, because they believe believed that it has many medicinal properties.  Experiments have shown that CBD is not addictive, and it is safe to use.

What does CBD oil do?

Among others, CBD acts on the cannabinoid receptors – but what are those?

Receptors are proteins that are the “eyes” and the “ears” of the cells. They receive messages from the blood and tell the cells what to do.

Endocannabinoid receptors are receptors in the human body. Several types exist, and these are the two main ones:

  • CB1 (mostly in the brain and in the central nervous system) and
  • CB2 (mostly in cells that make up the immune system).

Endocannabinoids are internal cannabinoids that bind to the cannabinoid receptors. Together with the receptors they form the endocannabinoid system.

The endocannabinoid system regulates many systems and processes in the body, including:

  • the immune system,
  • the digestive system,
  • inflammation processes,
  • energy processing,
  • mood and stress, and
  • fertility.
Human Endocannabinoid System - Endocannabinoid System horizontal infographic illustration about cannabis as herbal alternative medicine and chemical therapy, healthcare and medical science
The human endocannabinoid system

What is CBD oil good for?

When the endocannabinoid system is not working properly, certain illnesses occur.  As such, phytocannabinoids, especially the non-psychotropic CBD, have very high therapeutic potential.

The reason for this is that CBD has a wide spectrum of action, meaning it acts on many aspects of our body. For example, in addition to the cannabinoid receptors, it also acts on or modulates the function of other receptors as well, especially in the brain

CBD’s promise as a medicine comes from its potential:

  • to act on the immune system (immunomodulatory and anti-inflammatory properties) and
  • to protect the nervous system (neuroprotective and analgesic properties).

Additionally, CBD has beneficial effects in

  • seizures and epilepsy, and
  • diabetes as well.

Given that CBD induces cell death (apoptosis) in cancer cells but not in healthy cells, it has potentials in the treatment of various forms of cancer.

Several research studies have examined the effect of CBD, and they identified 18 areas with therapeutic potential.

18 proven CBD oil benefits

#1. Anti-inflammatory – potential as treating inflammation

In preclinical laboratory (in vitro) and animal experiments, CBD had the following effect:

  • suppressed the adaptive (specific) immune system
  • boosted the innate (non-specific) immune system
  • increased the number of natural killer T-cells
  • decreased the number of lymphocytes (white blood cells).

As such, CBD has shown potential as an inflammation suppressant.

Read more about CBD against inflammation (btw, you can find the same link at the bottom of this article, so keep reading…)

#2. Analgesic – potential as alleviating pain / pain killer

In animal models, CBD alleviated neuropathic pain associated with chemotherapy (paclitaxel and cisplatin treatment)

  • without cognitive impairment,
  • without signs of addiction,
  • without weakening the cancer inhibiting effect of the drugs and
  • without measurable side effects.
Read more about cannabinoids for pain (btw, you can find the same link at the bottom of this article, so keep reading…)

#3. Antiarthritic – potential as treating arthritis

Arthritis could also benefit from CBD oil

In animal experiments, CBD treatment

  • prevented the progression of arthritis
  • alleviated joint damage
  • decreased arthritic joint swelling,
  • reduced proinflammatory biomarkers,
  • thickened the synovial membrane
  • without any apparent side effects.

#4. Anxiolytic – potential as an anxiety medication and sedative

The administration of THC but not CBD produced psychoactive effects

However, when both THC and CBD were administered together in a ratio of 1:10:

  • patients’ anxiety was relieved
  • without the appearance of psychotic symptoms.

#5. Antidepressant action – potential as treatment of depression

CBD injections into the brains of experimental animals reduced depressive behaviors.

#6. Antipsychotic benefits of CBD

Patients with acute schizophrenia have elevated anandamide levels, which are inversely associated with psychotic symptoms. Administration of CBD increases anandamide levels, suggesting the role of CBD in regulating psychosis.

Additionally, CBD prevented THC-induced psychosis and suppressed symptoms of psychosis with negligible side effects.

Psychiatry patients might benefit from CBD oil

#7. Obsessive Compulsive Disorder

CBD suppressed obsessive compulsive behavior in animal models.

#8. Antiepileptic benefits of CBD

The anti-epileptic and anticonvulsant properties of CBD are probably due to its ability to suppress the generation of seizures by blocking sodium channels and nerve impulse (action potential firing) in neurons

A 2:48 minute long animation video about CBD for epilepsy

#9. Anti-Alzheimer – potential as Alzheimer’s disease treatment

In animal models, CBD inhibited neuronal degeneration and astrogliosis.

CBD in combination with THC:

  • reverted memory impairment (in both early and late Alzheimer stages) and
  • reverted beta-amyloid plaque formation (only in early stages).

Moreover, mesenchymal stem cells treated with CBD

  • prevented the formation of both neurofibrillary tangles and beta-amyloid plaques.

#10. Antidiabetic benefits of CBD – potential in diabetes treatment

In animal models, CBD reduced both insulitis and the prevalence of diabetes.

#11. Cancer treatment potentials

In cell culture laboratory and animal experiments, CBD

  • killed cancer cells,
  • decreased tumor growth
  • lessened tumor cell division,
  • reduced tumor size,
  • inhibited cancer metastasis
  • inhibited cancer cell invasion, and
  • prevented angiogenesis
    (the formation of new blood vessels).

Scientists found these effects for:

  • breast cancer,
  • glioblastoma,
  • lung cancer,
  • melanoma,
  • neuroblastoma, and
  • prostate cancer. 

CBD exhibited its anti-cancer properties acting in cancer cells only by:

  • increasing apoptosis (programmed cell death)
  • boosting autophagy (the body’s cleaning out damaged cells)
  • rupturing cancel cell membranes
  • activating killer cells.
At the same time, CBD did not harm healthy cells.

 In many of the experiments, a combination of CBD and THC (mostly in a ratio of 1:1) synergistically amplified anti-tumor effects.

The most effective treatment was when traditional cancer therapies – either radiation or cancer medications (such as bortezomib or carfilzomib for myeloma) – were combined with a blend of CBD and THC.

Read more about CBD oil for cancer (btw, you can find the same link at the bottom of this article, so keep reading…)

#12. Chronic obstructive pulmonary disease benefits of CBD

In animal models of asthma and COPD, CBD:

  • decreased levels of proinflammatory cytokines (proteins that promote inflammation),
  • and thereby suppressed lung inflammation.

#13. Crohn’s disease potential

In animal models of inflammatory bowel disease (Crohn’s disease and ulcerative colitis), CBD:

  • stimulated both epithelial and endothelial wound healing,
  • mitigated colitis
  • reduced tissue damage
  • reduced intestinal hypermotility.

#14. Autoimmune disorders and organ transplantation

In animal models of autoimmune myocarditis, CBD:

  • alleviated the condition
  • because it decreased the expression of proinflammatory proteins (interleukins).

Consequently, CBD reduced:

  • oxidative stress,
  • inflammation, and
  • tissue fibrosis.

A 3:36 minute long animation video about CBD for autoimmune disorders

#15. Anti-ischemic benefits of CBD

In animal models of hypoxic ischemic brain damage, CBD administered after the incident reduced:

  • damage,
  • apoptosis,
  • astrocyte damage, and
  • necrotic neurons.

#16. Liver fibrosis

In vitro studies of liver fibrosis, oral CBD administration resulted in:

  • increased lipolysis
  • reduced liver triglyceride levels.
Picture of brain symbolizing neuroprotective effect of CBD oil

#17. Anticerebral malaria action

In animal models of malaria, CBD:

  • exhibited neuroprotective effects,
  • reduced the production of proinflammatory proteins,
  • inhibited memory deficits
  • lessened anxiety, and
  • improved survival

#18. Neuroprotective effect in multiple sclerosis

In animal models of multiple sclerosis, both CBD and palmitoylethanolamide (PEA) administered separately, decreased:

  • demyelination,
  • neurodegeneration,
  • neurobehavioral deficits,
  • inflammation,
  • axonal damage,
  • apoptosis,
  • the expression of proinflammatory cytokines and
  • the expression of inflammatory markers.

However, coadministration of CBD and PEA antagonistically reduced the therapeutic effect.

On the DNA level, CBD:

  • suppressed proinflammatory genes and
  • enhanced anti-inflammatory genes.

Reference

Noreen, N., Muhammad, F., Akhtar, B., Azam, F., Anwar, M.I. Is cannabidiol a promising substance for new drug development? A review of its potential therapeutic applications (2018) Critical Reviews in Eukaryotic Gene Expression, 28 (1), pp. 73-86.

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